They need tanks with a higher volume, not mass, around 4x more, and 8x more with you are using only LH2 (for nuclear engines). Look at this infographic of Saturn V, the first stage make around 50% of the rocket volume, but have around 80% the weight. That's because it uses Kerosene and O2 (what the Liquid Fuel and Oxidizer in KSP best represents), and the upper stages uses mostly LH2 and O2, having a lower density.  Another example is the Shuttle. The orange tank (with LH2 and O2) weig
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