Hey look almost all the work already done for me.  Without having an enormous rocket, there is a practical limit to how much dV something with an ISP of 325 can get you. Unfortunately, as pointed out, NTRs are considerably heavier than their chemical counterparts. In fact, they pretty much always will be because there is a limit to how small they can be made. So even if TWR had no bearing on the decision to use one, the smallest an NTR can be made and still function is 1770 kg per the study
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