I have also been having this problem. I haven't found a solution per se, but I have found a workaround that allows me to continue using Tweakscale. BEFORE going to the tracking center and loading up your ship, go to the VAB. You don't have to do anything there, but you have to go there. (I suspect doing this initializes Tweakscale properly, whereas going straight to your ship does not.) Once you've been there, you can go to the tracking center and activate your ship, and it won't fly apart. It seems to be a pretty reliable, if clumsy, workaround.