I found a solution. I also had this problem when using OpenGL mode or Direct3D11 mode, using popupwindow worked as a fix, but as Smashbrown says it doesn't decrease memory usage nearly as much as full screen mode. Changing my video card drivers (I have a Geforce 760) did not seem to have any effect. What seems to fix this problem of 'fuzzy' or 'soft focus' graphics is to disable all anti-alaising settings in the nvidia control panel.