People were having issues with opening the program, throwing out messages to the effect of
Could not load file or assembly 'Assembly-CSharp,
And that it says it is from a network location. I have used this information to track down the issue. It does not mean that it thinks that it's trying to load dependencies from a network drive, but rather is complaining that it's trying to load a DLL that you got from the internet, and your .NET framework refuses to trust it. The fix for this issue is going to your KSP installation folder, then to KSP_Data > Managed and right click on each DLL containing the word "Assembly" and click on the Properties window. Right down the bottom of the General tab, it has a checkbox called "Unblock" check this box, then hit OK. repeat with all the DLLs that contain "Assembly" and it should open up without any issues.