Kakorrhaphiophobia

Hello Folks. Did a fresh KSP install last night, and obviously I also added a few mods that I have not tried before, to my already inadvisable collection. -New game (career/sandbox). -Load a very basic version of VTOL aircraft that used to work last time I played in 1.2 -Start TCA as usual, seems to be working. As soon as the craft leaves the runway, the game glitches, the whole Kerbin disappears and I'm left with the skybox and still somewhat responsive GUI. Reverting to launch leaves me with transparent airplane parts. Obviously it's not related to TCA, but rather to my horrid GameData folder. Is this ... a known incompatibility, or should I start painstakingly removing mods one by one? Thank you.