I have been playing on a 24 inch 1920x1080 screen. I am really not a fan of the pixellated nav ball. It makes it incredibly hard to read. I fly with a real AI and even way back in the day I can tell you they weren't pixellated. I am guessing the low resolution makes it even harder to use. The same goes for the inconsistency with text. Sometimes it is nice and crisp and other times a really weird font that is not pleasant to read/decipher. For example the manoeuvre node text box 'Required deltaV' is squished and very zx spectrumy or the SAS/RCS info around the Navball. Then to contrast the altitude on the Navball is nice to read.
Personally I don't like the location of the nav ball either. A lot of time is spent flying off this so my head is no longer pointing at the neutral position in the center of my screen. Instead I am off axis and down. Could there be an option to position it in the center so my neck isn't tweaked so much ?
The parts manager is quite obtrusive. If I want to just view one part I still have this huge window up. It is useful in its own right but a lot of the time the whole stack isn't required.