i think that the idea of ksp going into a galactic scale would be great even though it would take some time it would be fun, i think that as for distance and point precision error it could be solved by using stars and maybe even planets as 'hot spots' say you are headed to a star that\'s pretty far away from kerban like three light years. those two stars have both have point precision spheres that overlap. once you are in that overlapping spot the two stars and kerban (kerbans sphere is infinite so that it can give a third point of focus )then target your exact location by say hitting you with a signal or whatever computers do and the computer now knows exactly where you are in space and then there\'s no point precision error. as for loading up the game you could do it as a mixture of minecrafts chunk loading and kerbans sphere of loading quality first it loads the 'chunks' in low quality and as you get closer the quality gets better. and sorry for the mouth full!
