I don't want to stray to far from the original topic, but the OP's problem from vessels that have a large part count is due to the high number of physics calculations, not just the RAM limit. Right now, the real bottleneck of KSP is the CPU. Multi-threading and 64-bit applications would definitely help, but as others have said, very hard to implement. (part of the multi threading problem is the difficulty of coordinating a bunch of physics calculations at the same time on different threads) As for pagefile and virtual ram, I don't know very much, but I just wanted to make sure that we don't forget the other bottleneck's that KSP has.