The Pitch: Kerbals get "a little weird" the longer they are in space. Weirdness manifests as erratic behavior, untidy hair and surroundings, getting "creative" with supplies, and anything else a crazy kerbalnaut may get up to.
Objective: Have a "life-support / food / supplies" mechanic that makes no extra demand on the player, and yet is also hilarious.
The rate at which "getting weird" sets in depends on loneliness, amount of cabin space, quality of communication home, etc. The player won't acutally need to address "getting weird" to play the game normally, but it could lead to more Kerbal empathy in general.