I just started playing around in the Jool system this weekend so I'm definitely not an expert on getting to it's moons. But by far the most efficient way I've found to get in a stable orbit is to get a good equatorial trajectory from your transfer orbit, aerobrake around Jool at 119km, which should line you up to make an encounter with Laythe(or close to it), then aerobrake around Laythe at ~25km. Doing this should only cost you about 50 m/s of adjustments on top of your transfer burn. The key is having a good trajectory from your transfer orbit.