Pre-rotating my craft in the VAB, and, does this affect SAS modules?

[tfabris]

When creating or editing new spacecraft in the VAB, I have taken to starting it off with the command capsule pre-rotated 1/4 turn (press "Q" once with the capsule "picked up" IIRC) so that, when I finally put the craft on the launch pad, it automatically starts off facing eastward. This makes the launch and the gravity turn simpler (at least to my monkey brain) so that I'm simply nosing over instead of tilting right (or rotating right then nosing over).

I've noticed that I have to make sure to do the same thing with docking ports and remote-control modules that I add to the craft. Basically, anything that I can select "control from here" for. If I don't rotate those parts to match in the VAB, then when I select "control from here" for those parts, they are not aligned the same way as the capsule. Those parts seem to contain a handy marker or polarization indicator to make that process easy for me, so that I can tell which way they're rotated in the VAB.

So far so good.

My question is probably a silly one, is this:

Does the same need-for-proper-rotation apply to SAS modules? They don't seem to have a polarization indicator. I'm wondering if, sometimes when I have trouble rotating the ship via SAS reaction wheels, it's because various modules are fighting each other, such as the SAS built into the command capsule rotated one way is fighting the SAS ring I installed on the ship that I didn't rotate. Is that possible? Or do the SAS modules Just Work no matter what rotation they have?

[UbioZur]

Docking ports / pods does have a up and rotation orientation because they can be used as reference points for the navball (the control from here).

Reaction whells does not have that and so work the same way no matter how you put them.

One of my suggestion for the first remarue is to design your rocket without rotation first, and then rotate all the rocket, so you have the orientation you like for the launching.