As soon as I mastered orbital rendezvous/docking, basically every mission outside LKO has involved a payload/mission vehicle with a whole slew of support launches. Any given mission takes a while using this approach, but it allows me to get a lot of work done where it is I have gone. Last week I started a lander-probe mission to the mun because I had unlocked a few science parts (I use FASA) since my last landing. Built a 6x symmetry science section and attached it to a ~3,300 d/v lander. This was enough to land, hop to at least one other biome, and then safely return to a parking orbit. Because I'd overdesigned my munar transfer stage, I actually came out ahead and managed to hit three biomes before returning to orbit (was tight enough that I wasn't sure it would be very circular, but it worked out pretty well). Fuel tanker #1 was already waiting in orbit, adjusted/burned/waited as appropriate to dock and refuel. Lander went back down for two more biomes. Back up, tanker #1 had enough fuel to set up another rendezvous and supply the lander with enough gas to go down and hit one last biome. Returned to orbit, rendezvous with tanker #2, refill and head home. Performed soft landing not terribly far from KSC.