A real life Venus ascent would likely be quite challenging. KSP's Eve is a cakewalk be by comparison. While Eve's atmospheric pressure of 5 atmospheres causes Kerbaldom severe rocketry problems, the real life Venus's atmospheric pressure is a staggering 92 atmospheres. Pushing a rocket upwards through that soup would require a lot of energy -- or a completely different ascent strategy. And you need to build your entire spacecraft like a submarine, with a reinforced pressure hull to keep the whole thing from imploding. However, dealing with the atmospheric pressure is probably the EASY part. The killer is the temperature -- around 462 degrees Centigrade (862 Fahrenheit). Typical solder melts at 183 C or 361 F, so you're going to have trouble with electronics -- and probably everything else, too. If you can solve the temperature problem -- and that's a HUGE "if" -- I imagine you would want to make use of the dense atmosphere to ascend by using either wings or some sort of balloon. On the other hand, getting down should be very, very easy. Terminal velocity is low enough to land softly without propulsive landing or even parachutes. (The earliest Russian Venera Venus surface probes died before reaching the surface because the descent under parachute took so long that the batteries were exhausted before reaching the surface. Later Venera probes used parachutes to slow down -- then cut the chutes 50 km up and floated down to a soft landing without a parachute.) And did I mention the atmosphere contains sulfuric acid clouds? Yet one more challenge to be overcome. Given the extreme temperatures, if you wanted a surface sample, it would need to be a very fast mission. No loitering on the ground. We know how to get down -- pre-chill the spacecraft before deorbit, brake in the upper atmosphere, then use very low drag descent systems to get down quickly. Slowing down is easy -- imagine the overpowered KSP airbrakes -- except it really works on Venus. Once down, almost immediately you'll need to grab your surface sample, and ascend back up. Probably some sort of lighter than air system would be best. An inflated balloon should be able to get you up in the atmosphere pretty quickly, above a lot of the pressure and heat. Then some soft of rocket or rocket/plane combination to get you the rest of the way to space and give you orbital velocity. In KSP, almost every problem is a matter of getting enough delta V. On Venus, however, survival is the biggest problem.