Yes, resizing works much better. And MechJeb's dV readout helps immensely (before I was calculating mass and ISP and using those to calculate dV- a little bit time consuming). Plus, Ferram's launch vehicle tutorial helped me figure out which engines to use. And now that I know the TWR that I need for each stage, I can use basic physics to calculate the kN range that I need engines to be for future rockets. Finally put my first satellite into orbit!
RO makes a world of difference (see what I did there?). With stock KSP physics I would just build whatever I wanted, stick the biggest rocket I could make stable under it, and shoot away. It got almost... Boring. RO may be many things (a good way to lose hair comes to mind), but never boring.
Anyway. For the moment I'm working on my first manned mission. I'm sure I'll have more dumb questions later, but for the moment I'm happily building away. Thanks for your help!