One of my issues is that I have an aversion to larger timewarps, especially with the current brokenness of the lab. I think the only think that would really cure me of this is some in-game penalty for "wasting" time. I don't really like playing heavily modded, but maybe I should make an exception here.
Even then, without Kerbal Alarm Clock (or some similar mod), getting the transfer windows correct is pretty tricky with huge delta-V wastage. Now, to be fair, you can build massive rockets with huge amounts of excess delta-V, so really it becomes a question of efficiency.