Unfortunately I just can confirm the 'unable to save' problem. In my case I was using switching between ships in a rendevou using the [] when the ships just disappeared! I still have their icon and the orbit on the map ('M') but I cannot anylonger switch to them (nothing happens when I click, if use [] the game says there are no other vessels near by). Aditionally the menus become empty for any other vessel, for example, the resources menu that shows the propellants is just empty doesn't matter to what other ship I change and I can not longer control the vessels.
I upvoted the bug djr5899 created: https://bugs.kerbalspaceprogram.com/issues/26961
I think this bug is high severe (now it's severity is low), at least for me the game became unplayable :(
Somebody downgrade its KSP version to 1.10.1. I don't know how to do that but I will investigate. Up to now, I cannot recomend to upgrade to 1.11, which it's a pitty. I was very excited about it.