Besides the many bugs the game breaker for me is with saving and loading my rocket designs.
They don't seem to show up sometimes, mainly after reverting back to VAB after a failed launch, I'd go to save any changes i make to my design and my files wont show up. Its the same with loading too, the only files that show up are the ones that are included with KSP2, not my custom ones.
The first time i after starting the game seems to be fine, after that it just keeps getting worse, to the point where i lose my work ... So frustrating!!!