Happened to me a few times, quicksaved before decoupling supporting boosters; trajectory disappears after staging. Decoupled boosters that got the debris class after staging still had a trajectory, worth to mention that these were connected to the main booster with a fuel line. Managed to workaround it by moving boosters decouple action to the next stage.
What's more, after quicksaving after trajectory disappeared and loading this save, the vehicle loses all its speed and just free falls vertically.