Null_Pointer

So, if a player had FAR installed (to have a better aerodynamic model that takes account for the lift that wings produce), would a horizontal takeoff SSTO with jet engines have greater fuel efficiency than a vertical takeoff SSTO that also used jets?

I've noticed that some KSP players create Space Shuttle type spaceplane designs (or even horizontal takeoff SSTOs). Of course, this may be for role playing purposes, but it got me thinking -- what are the benefits of a horizontal takeoff jet-powered space plane versus a vertical takeoff SSTO (which also has jets to reduce fuel consumption, similarly to Scott Manley's reusable space program launch system)? I haven't had to much experience, and I've only just started using the B9 aerospace pack (which may invalidate what I'm about to say), but it would appear that horizontal takeoff SSTOs don't have as much payload capacity, so if one was to want a SSTO design for lifting large quantities of fuel/cargo, a vertical takeoff SSTO would be best. Is this still the case with B9 aerospace (since the B9 mod adds some pretty high capacity fuel tanks and some pretty large aircraft)? Also, what are the pros and cons of a vertical takeoff SSTO and a horizontal takeoff SSTO?