I'm running in 1440x900 resolution which is probably lower than most these days, but I find certain text lines almost completely illegible - specifically, stage dV, TWR, and fuel readouts, plus the "location path" label in the upper left (it says something like Kerbin/KSC/VAB). The part descriptions you see when pressing shift over a part in the VAB is not quite as bad, but I still have to squint to read it. Overall there's a huge size range between different bits of text.
The pixelated font *might* be ok if we could adjust and standardize the font sizes, but probably any other font (except wingdings) would be more readable.