Hmm. I run 120 mods, including hi res Better Atmospheres, hi res Kerbin retexture. And tons of quality of life plugins (precision node, kac, rcs build aid, eex, editor filter extension, parts quick search, ker), and gameplay effects like. Tac life support, eva fuels, reaction wheels nerf, remote tec, kis, ctt, etc.
My first playthrough was with single parts mod - surface lights.
But now I've became part maniac.
Now my install has AIES, HGR, KW, OPT, SXT, Ven's stock revamp, Cacteye, Tarsier, mk4 spaceplanes, KAX, mk3 part expansion, mk3 parts expansion mini (with shuttle nose cone), USI derp pack, karibu, explorer pack, oblivion, procedural fairings everywhere, turbonisu, space station science, Dmagic sciense, universal stotage, interstellar, quiz tech, kax extension, B9 and something else i dont remember right now.
Also almost all of contacts packs available
Other than great loading time, and sometimes crash ( 20~30 % probability ) on start, the game runs rock solid for several hours. Around 19000 module manager patches :)
So, yes i can have all the toys to play with.
I have 16GB of RAM and use 64 bit "hack"
Win 8 x64 if it matters