Thanks.
Sure, from the KSC screen, through the menu (either pressing Esc or clicking the red button in the bottom right corner), then selecting "Save game..." (see screenshot #1).
Well, to me it always worked in a pretty conventional way (except you cannot go to the KSC under some circumstances without being set back, and hence you are unable to save some precise moments - mostly those ones when your ship is under acceleration of any kind).
The thing is that when you click "Save", the game writes "Qucksaving..." in the right part of the screen, and actually saves the game; however, if you press "Enter" instead, it does neither and just shuts the menu. Maybe it's not exactly a bug in a common sense of the word, but it's a really counter-intuitive and hardly user-friendly feature anyway.